Endocrine Abstracts

Introduction: There are known biological differences between men and women in coronary heart disease. It is important to know these differences in order to avoid inequalities in prevention, diagnosis and treatment of this pathology.Methods: We designed a retrospective, descriptive study in which we included all diabetic patients admitted to 3 different hospitals in Cádiz province with acute coronary syndrome and diabetes in 2016. Demographic data an...

Introduction: There is a lack of epidemiological data on the distribution of haptoglobin and C677T of MTHFR polymorphisms in Caucasians type 2 diabetic patients. The contribution of these two genetic factors to hyperhomocysteinemia and hypercysteinemia can be useful to prevent cardiovascular events and to reduce public health costs. The aim of this study is to evaluate the contribution of haptoglobin and C677T polymorphisms for hyperhomocysteinemia and hypercysteinemia in Port...

Rationale: Secondary prevention of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM) has shown benefit but the level of control is still disappointing. Most of the results are documented within clinical trials. There isn’t enough information in routine clinical practice at short-term tracing. The main aim of this study is to collect information about the level of control of major risk factors in non-selected patients.Met...

Introduction: Obesity has been associated with a low-level activation of the acute-phase response. The aim of the present study was to compare inflammatory parameters in patients with obesity and a control group, and to evaluate the effect of weight loss on these parameters.Methods: Sixty-seven severe or morbid obese patients (51 women, 16 men), aged 34±11 years, were compared with 67 normal-weight controls (45 women, 22 men), aged 32±10 years....

Introduction and Objectives: Preperitoneal fat is an ectopic visceral adipose tissue with a significant proinflammatory metabolic impact. The objective of this study is to measure preperitoneal fat by nutritional ultrasound at discharge, 3 months and 6 months in a cohort of patients who required admission to the Intensive Care Unit (ICU) due to severe COVID-19 pneumonia, and to analyze the differences based on the presence or not of previous DM.Material ...

The improvement of glycemic control and body weight reduction by GLP-1 receptor agonist (GLP1RA) has been demostred in randomized clinical trials, but comparative studies of the efficacy of different GLP1RA in real world and clinical practice setting are limited.Objectives: To compare the efficacy of liraglutide (LIRA), exenatide once weekly (EQW), and lisixenatide (LIXI) treatment in a real-world and clinical practice setting.Meth...

Introduction: Graves’ and Hashimoto’s diseases are considered two extremes of the same autoimmune thyroid disease. Spontaneous conversion from hypothyroidism to hyperthyroidism is uncommon. On the other hand, Graves’ disease typically improves during pregnancy and worsens after delivery. We describe a patient with an unusual course of thyroid disease during pregnancy.Case report: An 33-year-old woman, with a two-year history of hypothyroid...

Background and objective: The upcoming new marketing presentations GLP1 analogues with a dosage more comfortable for patients, we wanted to revise the two we currently have on the market. The target of this study is to determinate glicated hemoglobin (HbA1c) at 6 months of treatment, changes in weight, body mass index (BMI) and tolerance.Design and methods: Observational study that included 60 patients with diabetes mellitus type 2 followed in two Intern...

Background and objective: Combination therapy in diabetic patients is seeking better clinical outcomes by acting on different targets in the pathophysiology of the disease.Insulin glargine provides excellent glycemic control, especially in the fasting glucose control, in spite of a increasing in weight, compared with exenatide which is more effective in controlling postprandial glycemic and in reducing insulin resistance, plus a reducing effect on the we...

Background: Bariatric Surgery (BS) is an effective treatment for the metabolic control of obese patients. One of its purposes is to improve the lipid profile and reduce cardiovascular risk.Aims: • To determine the changes in lipid profile and other cardiovascular risk factors before and one year after BS.• To assess differences in lipid parameters depending on the surgical procedure used.• To a...